Dentistry is not just teeth or mouth, is the window into human health. All my academic research has always focused on periodontology, to engage, educate, excite, and assist general population, students, and colleagues in understanding dental procedures, that are required after a correct oral hygiene has failed. Consequently, due to my background in periodontology; at our laboratory we have focus on different biomaterials for bone regeneration. Simultaneously how to improve other alloplastic materials and the evaluation of dental implants, which are needed in treatments aimed to regenerate the lost tissues around teeth; including scope of the field, what to expect in function, and aesthetics.
My bachelor’s in dental surgery training and education are from the National Autonomous University of Nicaragua. I started my academic training and research experience by completing a two-years program in Master of science at Taipei Medical University, where I transitioned my research with a PhD.
The long-term research project that has I worked in the last years focuses on Reconstruction of osseous defects, as performed in the fields of periodontics, maxillofacial surgery, implantology and orthopedics, often can be treated with the use of autogenous bone. Autologous bone grafts are considered the gold standard in bone regeneration due to their osteogenic, osteoinduction, osteoconduction, and osseointegration characteristic. However, it is challenging to use only autogenous bone when these defects are large and complex and require adequate bone volume at the desired locations. Availability, which in some cases is shallow, and autograft acquisitions come with a cost for the patient including additional surgical incisions, increased postoperative morbidity, weakened donor bone sites, and potential complications.
These adverse effects make it necessary to discover alternative options that mimic the physicochemical and biological performance of natural bone-derived apatite, such as allografts, alloplastic materials, or xenografts. A disadvantage of fresh bone allografts is the possible rejection by the host immune system. In addition, alloplastic materials are either more complex or costly when compared to biological apatite that is directly prepared from hard tissues of animals (e.g., bovine, porcine, and cuttlefish bone). Nowadays, porcine bone is considered to have the closest resemblance to human bone in multiple studies in terms of macrostructure and microstructure, chemical composition, and remodeling rate. Porcine graft also presents an abundant supply, making it an excellent candidate as bone graft material for reconstructing osseous defects. Consequently, due to my background in periodontology my primary studies have focus on Porcine graft and other bone grafts materials, including membranes for bone regeneration and how to improve these biomaterials.
Other studies have as pivot the evaluation of bone remodeling around dental implants and other problems, like its interaction with bacterial adhesion and fibroblast. Dental implants have been well developed as a breakthrough in dentistry. This success has brought dental problems like peri-implant mucositis and peri-implantitis, diseases that has become part of the dentist’s daily practice main target for prevention and treatment. Titanium (Ti) has been considered the suitable material for fixtures and abutments in oral rehabilitation for its osseointegration in bone capabilities and innocuous relation with surrounding soft tissues.
Recently we have been focusing on the Development of a new 3D collagen scaffold mixed with fibronectin that can reabsorb slowly, have a good mechanical strength and strong resistance against tearing. Research on the new 3D collagen scaffold mixed with fibronectin viability and improvement of new bone formation during Guided tissue regeneration (GTR) treatments. GTR with bioabsorbable collagen membranes (CM)which is commonly used for the treatment of periodontal defects. Type I collagen comprises approximately 95% of the entire collagen content of bone and about 80% of the total proteins present in bone. Fibronectin will be used to improve the collagen because is known to retain biological activities, by stimulating wound healing as a scaffold for the proliferation of mesenchymal and endothelial cells.